Biophysics (Dept Elec-III) (2180411)  

Syllabus

Sr. Topics Teaching Hours Module Weightage
1
UNIT I: Laws of Physics and Chemistry
Introduction, Quantum Mechanics, The Electronic structure of Atoms, Molecular Orbitals and Covalent Bonds, Molecular Interactions, Stereochemistry and Chirality, Thermodynamics, Radioactivity, Physics of membrane potentials.
6
9 %
2
UNIT II: Physico-Chemical Techniques to Study Biomolecules
Introduction, Hydration of Macromolecules, Role of Friction, Diffusion, Sedimentation, The Ultracentrifuge, Viscosity, Rotational Diffusion, Light Scattering, Small Angle X-ray Scattering
8
12 %
3
UNIT III: Spectroscopy
Introduction, Ultraviolet/Visible Spectroscopy, Circular Dichroism (CD) and Optical Rotatory Dispesion (ORD), Fluorescence Spectroscopy, Infrared Spectroscopy, Raman Spectroscopy. Electron Spin Resonance
12
19 %
4
UNIT IV: Light Microscopy and Electron Microscopy
Introduction, Different types of Microscopy, Bright field Spectroscopy, Dark field Spectroscopy, Phase contrast Spectroscopy, Fluorescence Spectroscopy, Polarising Spectroscopy, Electron Optics, The Transmission Electron Microscope (TEM), The Scanning Electron Microscope (SEM), Preparation of the Specimen for Electron Microscopy, Image reconstruction, Electron Diffraction, The Tunneling Electron Microscope, Atomic Force Microscope
12
19 %
5
UNIT V: X-ray Crystallography
Introduction, Crystals and Symmetries, Crystal Systems, Point Groups and Space Groups, Growth of Crystals of Biological Molecules, X-ray diffraction, X-ray Data Collection, Structure Solution, Refinement of the structure
10
16 %
6
UNIT VI: NMR Spectroscopy
Introduction, Basic Principles of NMR, NMR Theory and Experiment, Classical Description of NMR, NMR Parameters, The Nuclear Overhauser Effect, NMR Applications in chemistry – biochemistry, biophysics and medicine.
10
16 %
7
UNIT VII: Biomechanics and Neurobiophysics
Introduction, Biomechanics of Cardiovascular system, the nervous system, Sensory mechanism of eye, physical aspects of hearing
6
9 %